Prescribing Information. Safety Data Sheet. The search will retrieve any scientific documents from the medical information database where the search terms match either the title or content of the document. The response s are not intended to offer recommendations for administering Novo Nordisk products in a manner inconsistent with approved labeling.
Patients with renal or hepatic impairment may be at higher risk of hypoglycemia. Patients and caregivers must be educated to recognize and manage hypoglycemia.
Untreated hypokalemia may cause respiratory paralysis, ventricular arrhythmia, and death. Monitor potassium levels in patients at risk for hypokalemia if indicated e. Patients should be observed for signs and symptoms of heart failure. If heart failure develops, dosage reduction or discontinuation of the TZD must be considered. Adverse Reactions Adverse reactions observed with insulin therapy include hypoglycemia, allergic reactions, local injection site reactions, lipodystrophy, rash, and pruritus.
Drug Interactions Drugs that may increase the risk of hypoglycemia: antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analog e.
Drugs that may decrease the blood glucose lowering effect: atypical antipsychotics, corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens e. Drugs that may increase or decrease the blood glucose lowering effect: alcohol, beta-blockers, clonidine, lithium salts, and pentamidine. Drugs that may blunt the signs and symptoms of hypoglycemia: beta-blockers, clonidine, guanethidine, and reserpine.
Initiating insulin therapy in type 2 diabetes: a comparison of biphasic and basal insulin analogs. Diabetes Care. Intuitiveness, instruction time, and patient acceptance of a prefilled insulin delivery device and a reusable insulin delivery device in a randomized, open-label, crossover handling study in patients with type 2 diabetes. Then your card will be ready to be shared with your specialty pharmacy. I Disagree I Agree. Do not withdraw insulin from the pen using a syringe.
Warnings Humulin R U may cause serious side effects, including: Severe low blood sugar, which can lead to seizures, unconsciousness, and death. Severe allergic reactions. Get medical help right away if you develop a rash over your whole body, have trouble breathing, have a fast heartbeat, or are sweating. Swelling of your hands and feet. Tell your doctor if you are short of breath, have swelling in your ankles, or have gained weight suddenly.
This may occur in some people even if they have not had heart problems before. Low potassium in your blood hypokalemia. This can lead to severe breathing problems, irregular heartbeat, and death.
Do not use Humulin R U in an insulin pump or inject it into your vein or muscle. Do not take this medicine if you have low blood sugar. Common side effects The most common side effects of Humulin R U include: Low blood sugar hypoglycemia. Talk to your doctor about low blood sugar symptoms and treatment. Symptoms may be different for each person.
Allergic reactions, such as redness and swelling at the site where you inject. Skin thickening or pits at the injection site lipodystrophy. Itching and rash. These are not all the possible side effects of Humulin R U Before using Tell your doctor if you are pregnant or plan to become pregnant. Also tell your doctor about: Any allergies you have. Short-acting regular insulin is also available in U This is five times more concentrated than U regular insulin.
Long-acting insulin glargine is also available in U This is three times more concentrated than U long-acting insulin. Be sure to check the concentration of your insulin so you take the right amount. Insulin is made by different companies. Make sure you use the same type of insulin consistently. Rapid-acting insulins work over a narrow, more predictable range of time.
Because they work quickly, they are used most often at the start of a meal. Rapid-acting insulin acts most like insulin that is produced by the human pancreas. It quickly drops the blood sugar level and works for a short time.
If a rapid-acting insulin is used instead of a short-acting insulin at the start of dinner, it may prevent severe drops in blood sugar level in the middle of the night. Short-acting insulins take effect and wear off more quickly than long-acting insulins. A short-acting insulin is often used 30 minutes before a meal so that it has time to work. These liquid insulins are clear and do not settle out when the bottle vial sits for a while.
Intermediate-acting insulins contain added substances buffers that make them work over a long time and that may make them look cloudy.
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